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What is SIBO?

What is SIBO?SIBO is a condition characterized by excessive bacterial growth in the small intestine, leading to multiple symptoms and complications such as malabsorption and intestinal permeability.

Symptoms of SIBO
They are nonspecific symptoms, including bloating, abdominal pain, gas, nausea, indigestion, constipation and diarrhea. Risk factors for the development of SIBO include structural/anatomical problems, motility disorders, immunodeficiency, Decayed digestive secretions, old age and various medications (repeated use of antibiotics, PPIs, opiod analgesics). In symptomatic patients with underlying conditions or risk factors, evaluation for SIBO is required.
Genova's SIBO Profiles are non-invasive breath tests that capture hydrogen (H2) and methane (CH4) gases in the breath given after drinking lactulose solution by the patient to assess excessive bacterial growth in the small intestine.
Two different SIBO test options of 2 or 3 hours are available for clinicians.
The 3-hour SIBO profile provides information on gas levels over a long period of time and is recommended for patients with slow gastrointestinal transit or constipation.

When should SIBO testing be considered?
Risk factors related to the development of SIBO in structural/anatomical problems, motility disorders, organ system dysfunction, advanced age, and the population of various drugs that alters the microflora of the intestine (used repeatedly antibiotics, PPI) facility.
SIBO examination should be performed in symptomatic patients with any underlying condition or risk factor.
Ailments that are often associated with SIBO include the following:
* IBS (Irritable Bowel Syndrome)
* Inflammatory Bowel Disease (IBD)
* Celiac Disease
* Fibromyalgia
* Rosacea
* Parkinson's Disease

What advantage does the SIBO breath test offer compared to other diagnostic tests?
Aspiration of small intestinal fluid (for culture and bacterial counting) is considered the gold standard for the diagnosis of SIBO, but it is not routinely performed because it requires complex and invasive techniques and has a high cost. As a result, experts recommend a breath test for the diagnosis of excessive bacterial growth in the small intestine.

What can clinicians and patients expect from a SIBO breath test?
In general, the clinical management of a SIBO patient includes antimicrobial therapy, prokinetic drugs, dietary supplementation, dietary interventions, and treatment of concomitant disorders.
Genova's SIBO profiles reflect the current state of scientific knowledge associated with the SIBO breath test and the interpretation of the results and are designed to optimize the management of the symptomatic patient.

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